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doi:10.2337/db07-1824 Yang X, Qiang Q, Li N, Feng P, Wei W, Hlscher C

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59 In MASLD patients with inadequate glycemic control on metformin, sitagliptin (a DPP-4 inhibitor) and liraglutide 1.8 mg daily showed no significant differences in improving LFC assessed by MRI-PDFF, visceral adipose tissue, and weight reduction

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Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus Usual Adult Dose for Weight Loss ORAL: Wegovy Tablets: Initial dose (days 1 through 30): 1.5 mg orally once a day Dose escalation: Days 31 through 60: 4 mg orally once a day Days 61 through 90: 9 mg orally once a day SUBCUTANEOUS: Wegovy Injection: Initial dose (weeks 1 through 4): 0.25 mg subcutaneously once a week Dose escalation: Weeks 5 through 8: 0.5 mg subcutaneously once a week Weeks 9 through 12: 1 mg subcutaneously once a week Weeks 13 through 16: 1.7 mg subcutaneously once a week If the 2.4 mg dosage is tolerated for at least 4 weeks and additional weight reduction is clinically indicated: Increase to 7.2 mg subcutaneously once a week