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175 Mitochondrial dysfunction is a defect in the early stage of PD and mainly includes impairment of the mitochondrial electron transport chain, alterations in mitochondrial morphology and dynamics, mutations in mitochondrial DNA, and anomalies in calcium homeostasis, 176 which are closely related to the PD phenotype

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all diabetes-associated changes were attenuated to some degree by insulin administration dosed to maintain euglycemic levels (Yono et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 201

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