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GLP-1 (Glucagon-like Peptide-1) Receptor Agonist: Focuses on insulin secretion, glucose-dependent insulin sensitivity, and suppressing appetite via the brain's reward centers

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Collectively, the data suggest that the GLP-1 receptor class of medications may have benefits beyond diabetes or weight management with direct implications for liver cancer risk

BI 456906 (survodutide), developed as a dual agonist for GLP-1 and glucagon receptors for the treatment of obesity and NASH, is structurally modified from glucagon [109]

In addition to this, GLP-1RAs may directly improve hepatic steatosis via the upregulation of fatty acid metabolism and insulin signalling pathways [12]