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Table 1: Key Findings on Natural GLP-1 in Joint Fluid and Arthritis Research shows GLP-1 is present in synovial fluid , supporting the idea that therapies targeting this hormone could directly influence joint inflammation

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Based on the direct comparison described in the article, tirzepatide produced greater average weight loss than semaglutide in adults with obesity without diabetes

Clinical trial data using body-composition analysis show that fat mass accounts for the majority of weight loss, while lean-mass changes reflect normal physiologic adaptation to reduced body weight and energy intake. Understanding this distinction is criticalbecause muscle wasting and expected lean-mass adaptation are not the same thing

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