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methodological differences, interindividual heterogeneity, and intraindividual variability), large, high-quality studies are needed to assess the ability of host genetic variants using MR to mimic specific GM featureswhether specific bacterial species, genera, or metabolite productsto understand causal connections with type 2 diabetes pathogenesis

All of the blockbuster drugs have standard doses and standardized dose escalation regimens during the initiation phase of treatment

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According to the European guidelines (EASL-EASD-EASO), pioglitazone may be used in the treatment of NAFLD/MASLD in individuals with type 2 diabetes (off-label in those without type 2 diabetes)