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Promethazine (Phenergan): Alternative if Zofran ineffective

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In humans, Kelly et al

But it is also approved by the Food and Drug Administration (FDA) to lower the risk of cardiovascular events in adults with heart disease who have excess weight or obesity, and to treat adults with an advanced liver disease known as metabolic-associated steatohepatitis (MASH)

As discussed below, the development of unimolecular multi-agonists that stimulate GLP-1 receptors and other receptors such as GIP receptors and glucagon receptors (GCGR) can have beneficial effects on metabolism and increase metabolic rate at tolerable doses [57]