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Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes

The slowing of digestion from Wegovy combined with the unabsorbed fat from Orlistat might increase the frequency and severity of GI symptoms, potentially leading to significant discomfort and impacting an individuals quality of life

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Because the peak concentration of the medication doesnt happen instantly, taking the shot before bed allows you to sleep through the first few hours of the medications onset