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Hypoglycemia may occur in patients taking GLP-1 medications alongside insulin or sulfonylureas, though GLP-1 agonists alone carry minimal hypoglycemia risk due to their glucose-dependent mechanism

[7] [8] The concept of GLP-1 balance has gained clinical relevance with the development of GLP-1 receptor agonists (such as semaglutide and liraglutide) for glycemic control and, at specific FDA-approved doses, chronic weight management

However, these medications also face several challenges, including low stability in the body, short half-lives, poor membrane permeability, complex manufacturing processes, and high costs

Lancet Diabetes Endocrinol 2022
