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Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)

Lastly, a study evaluating the impact of IL-1 gene polymorphism, leading to increased IL-1 levels, was shown to correlate with an increased rate of kidney disease in T2DM, mainly diabetic nephropathy [8]

Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbll T, Warren ML, Bain SC

PMCID: PMC8572027