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Several mechanisms may contribute to the positive effects of GLP1RAs in preventing HF and influencing the outcomes for patients with either HFpEF or HFrEF

heterogeneity for CANVAS versus the other 12 CVOTs, p = 0.0007) [76]

A comprehensive medical history is essential to identify contraindications, including personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as GLP-1 agonists carry a boxed warning regarding thyroid C-cell tumors observed in rodent studies

The US Food and Drug Administration approved this first-in-class medication for the management of type 2 diabetes (T2D) in 2022 [2], for the reduction of excess weight in adults with obesity or overweight in 2023 [3], and for moderate-to-severe obstructive sleep apnea (OSA) in people with obesity in 2024 [4]

Some regain of two to five pounds is typical and often represents water and glycogen, not fat, particularly if any carbohydrate slip occurs