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[DOI] [PubMed] [Google Scholar] [69].Figlewicz DP, Evans SB, Murphy J, Hoen M, Baskin DG Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat

Semaglutide does not undergo significant hepatic metabolism and does not inhibit major cytochrome P450 enzymes, further reducing interaction risk

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Moreover, in STEP 8 [46], semaglutide 2.4 mg exhibited superior efficacy compared with liraglutide 3.0 mg, achieving a mean reduction in BW of more than 10%