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The confirmatory secondary outcomes included major kidney disease events (a five-point composite outcome)

3Aminoglycosides gentamicin, tobramycin, amikacin They can cause renal tubular toxicity, reducing magnesium reabsorption in the thick ascending limb of the loop of Henle

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Some individuals may present with nonspecific symptoms such as increased fatigue, confusion (particularly in older adults), or worsening glycemic control without classic urinary symptoms
