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Fatigue appears in 8-12% of users, though distinguishing medication-induced fatigue from diet-related energy deficits proves difficult

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Source: Hwang, et al JAMA Health Forum March 14, 2025 Implications for employers: This modeled study suggests that employers should at least offer access to the two combination generic medications for obesity if budgets allow

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23 The most commonly used off-label medicine is acetazolamide

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These typically subside as dosing stabilizes

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