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The volunteers were randomly assigned to receive semaglutide (up to 2.4 milligrams, the highest dose currently approved for obesity treatment) or placebo over a 72-week period

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In a systematic review of 55 double-blinded, placebo-controlled randomized clinical trials, GLP-1RA treatment was associated with an increased risk of cholelithiasis compared with placebo (RR 1.46, 95% CI 1.091.97) but not cholecystitis, cholangitis, or pancreatitis (63)

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A study of 72 adults with obesity found that those with the highest added sugar intake experienced the smallest increase in GLP-1 levels following glucose consumption