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Managing Gastrointestinal Symptoms Nausea, diarrhea, and constipation are manageable with the right clinical strategy

It is thought high homocysteine levels in antiepileptic drug users might increase the risk of epileptic seizures and systemic vascular events, including stroke, and reduce the ability to control seizures in patients with epilepsy

This is usually mild and localized, but it can be uncomfortable

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Pharmacological studies demonstrate that blocking either GLP-1R or glucose-dependent insulinotropic polypeptide receptor (GIPR) partially reduces Tirzepatide-induced insulin secretion, but only simultaneous blockade of both receptors eliminates this effect 36
