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[DOI] [PubMed] [Google Scholar] 99.Wunderlich CM, Hovelmeyer N, Wunderlich FT

J., & Owen, L

A 6-week phase 1 study of participants without T2D who had overweight or obesity found reduced activation (estimated from blood oxygen level dependent signal functional MRI) in certain brain regions relevant to appetite regulation in response to high-fat/high-sugar food images among participants assigned to tirzepatide 10 mg as compared with placebo [75]

hGPR17L regulation of GLP-1 secretion was Gq-independent and dependent upon Gi/o signaling, but was not correlated with MDL29,951-induced whole-cell cAMP signaling