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225,226 Therefore, the mechanism of action of GLP-1 RAs and a dual GLP-1/GIP RA can be characterized by modulating physiological properties within the model, enabling the prediction of altered pharmacokinetics for the affected drug

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Boston, MA Frequently asked questions In the SURMOUNT-1 trial published in The New England Journal of Medicine (Jastreboff et al., 2022), participants on weekly tirzepatide 15 mg lost an average of 20.9% of body weight at 72 weeks versus 3.1% on placebo