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Generation of smoke/aerosol, aqueous extracts, gasvapor phase (GVP) extracts, and total particulate matter (TPM) CS from 3R4F cigarettes was generated on a 20-port Borgwaldt smoking machine (Hamburg, Germany), and test aerosol from THS 2.2 was generated on a 30-port SM2000/P1 smoking machine (PMI, Neuchatel, Switzerland) in accordance with the Health Canada intense smoking protocol (puff volume, 55 mL