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9 With an increasing awareness of tobacco smoking hazards, several pharmacological interventions have been introduced in the smoking-cessation program such as nicotine-replacement therapies, e.g., gum, patch, lozenge, and inhaler, and non-nicotine based, such as varenicline, sustained-release bupropion, and nortriptyline

While it is impossible to be certain of the outcome of any particular case or of the amount of any possible adverse verdict, the Group believes that the defences of the Groups companies to all these various claims are meritorious on both the law and the facts, and a vigorous defence is being made everywhere

This, in turn, increases blood pressure, respiration, and heart rate