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Local necrotic flecks
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In our opinion, the increase in smoking with the universal custom of inhaling is probably a responsible factor, as the inhaled smoke, constantly repeated over a long period of time, undoubtedly is a source of chronic irritation to the bronchial mucosa. Tobacco Smoking As A Possible Etiologic Factor In Bronchogenic Carcinoma (10 pages) Original article by Ernst Wynder and Evarts A
