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As early as the 1970s, Tobacco Mosaic Virus (TMV) was shown to possess substantial interferon-inducing and antiviral activity in mammalian systems, comparable to synthetic interferon inducers, despite its inability to replicate in vertebrate cells ( Consistent with this framework, prophylactic induction of interferon responses can reduce susceptibility to SARS-CoV-2

In: Therapeutic Choices
We assessed study quality using the Newcastle-Ottawa Scale for assessing non-randomised studies in meta-analysis [24]

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