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Long-term nicotine use affects digestive health through multiple mechanisms: Altering gut microbiome composition and diversity Changing blood flow patterns to digestive organs Modifying nervous system signaling pathways Creating dependency for normal bowel function For people with Crohn's disease, continuing nicotine use can be particularly harmful

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They are also slightly more susceptible to ocular damage from nicotine use, as their bodies are not always able to repair the vascular damage compared to younger populations

38 Chemicals such as ammonia and ammonium compounds are added to tobacco products to increase the pH, 40 which may be increasing the delivery of nicotine to the blood, although this is not supported by biological studies
