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April 3, 1992

The effect was dose-dependent: the more someone used per week, the worse their vascular function. Worryingly, even relatively small doses of 2.5mg multiple times a week seemed to have a harmful effect

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Recent studies have indicated that acrolein modification induces functional defects in its targets, such as extracellular matrix (ECM) protein 7 , apolipoprotein E 8 and protein disulphide isomerase, during CS exposure 9
