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"The choice to air-cure or the choice to flue-cure is directly informed by the results of the tobacco that you get when you grow it in environment X versus environment Y." Weather and Climate Impacts Beyond the particular cultivation and curing methods, Jeremy notes the effects of weather and climate on tobacco

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Thereafter, CuBr (46 mg) and PMDETA (110 mg) were introduced into the flask

Smokes down to a fine ash at the bottom, no goopy mess

But other than its addictive properties (which incidentally appear reduced when separated out from other chemicals resident in the smoke) nicotine is a relatively benign drug