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In normal conditions, Nrf2 is sequestered in the cytoplasm through its binding to the repressor protein Keap1 (Kelch-like ECH-associated protein 1), resulting in the ubiquitination and degradation of Nrf2

[Crossref] Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (1995) An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

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