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LM: Methodology, Visualization, Writing original draft
F.et al (2013)
Lycopene is a naturally occurring carotenoid with potent antioxidant properties
Mechanistically, hyperoside inhibits cyclin-dependent kinase 6, thereby promoting dephosphorylation and nuclear translocation of transcription factor EB, which in turn upregulates PGC-1 and uncoupling protein 1 to activate thermogenic programs in adipose tissue
However, further mechanistic studies and human intervention trials are needed to better elucidate the relationship between diet, microbiota-dependent TMAO production, and its impact on human diseases
