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Management: Gentle massage of the area can help distribute the solution

However, its application in topical formulations is severely hindered by its rapid oxidation, intrinsic instability, and poor permeability across the stratum corneum

[PubMed: 17257897] 89

Before the chemotherapy drug starts, the patient often receives anti-nausea medications through the IV
While both natural sources of hesperidin and its supplements are safe, their use must take into account factors such as the desired therapeutic effect, potential side effects, dietary balance, and individual health conditions