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Patients were randomized to standard dose NAC (600 mg IV bolus before primary angioplasty and 600 mg orally, twice daily for 48 hours following angioplasty), double dose NAC (1200 mg IV bolus before primary angioplasty and 1200 mg orally, twice daily for 48 hours following angioplasty), and placebo

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Strategies aimed at stabilizing the mitochondrial membrane potential, preventing swelling, and enhancing ATP production or mitochondrial Ca uptake via the mitochondrial calcium uniporter may be beneficial