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There are multiple possible synthetic routes to obtain different cereblon ligand derivatives, and subsequent attachment to linkers for the construction of the final cereblon-based PROTACs
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It is being tested to combine ganitumab with Src inhibitor dasatinib in patients with embryonal and alveolar rhabdomyosarcoma, and with chemotherapy, radiotherapy or CDK4/6 inhibitor in Ewing sarcoma (Table 1)
