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In particular, in the spinal cord, mGlu2/3 and 5-HT 2A receptors colocalize at a presynaptic level and 5-HT 2A antagonists trigger positive allosteric modulations of mGlu2/3 autoreceptors in controlling glutamate exocytosis [19]
Think of it as a tool you add when the primary tool needs reinforcement, not something you deploy preemptively
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Completing full protocol durations rather than stopping when symptoms resolve helps optimize long-term tissue quality and reduces re-injury risk
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