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Even in low-selenium situations, GPx4 has been identified as a major enzyme for eliminating fatty acid hydroperoxides [105,106,107]

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Histology Euthanized fish were slit open from the anal vent to the gills, and the entire body was fixed with 4% paraformaldehyde in 0.1 M phosphate buffer (Muto, Tokyo, Japan)

doi: 10.3389/fendo.2016.00129 Received 17 May 2016 Accepted 06 September 2016 Published 10 October 2016 Volume 7 - 2016 Edited by Romesh Khardori, Eastern Virginia Medical School, USA Reviewed by Riccarda Granata, University of Turin, Italy