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Methylation represents a critical epigenetic marker on DNA and histone substrates [73] (Figure 1)

Since oxidative stress in the nervous system is one of triggering factors for CIPN, and an impaired mitochondrial antioxidant response after paclitaxel, oxaliplatin and bortezomib is thought to underlie CIPN [120], novel mitochondria-targeting antioxidants have also been evaluated

Conversion of canavanine to -keto--guanidinooxybutyrate and to vinylglyoxylate and 2-hydroxyguanidine

2024;S20901232(24) doi: 10.1016/j.jare.2024.10.038

177 Peripheral inflammation is associated with the activation of immune cells, including T cells, macrophages, and monocytes, which can breach the BBB due to their increased permeability in this disease state