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5.6 Personalized medicine and holistic approaches The increasing knowledge of the gut-brain-kidney axis offers the potential for personalized treatments, especially in CKD patients

Reviews have raised concerns because long-term safety and effectiveness are not well established

Despite the limitations of our lifespan data, findings from our cross-sectional studies in calorie-restricted mice provide robust evidence that glucagon receptor signaling is required for the healthspan benefits of CR and that glucagon receptor signaling at the liver is required for the CR-induced decrease in hepatic mTOR signaling, a primary driver of aging [17,18,19, 48, 97]

Baseline plasma VEGF-A levels and neuropilin-1 expression were identified as potential predictors of bevacizumab efficacy (160)

Examined BPC-157 in inflammatory bowel disease research models at oral doses of 10100 g/kg in rat models
