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Peer review Peer review information Nature Materials thanks Willem Mulder, Dan Peer and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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This imbalance is marked by Drp1 hyperphosphorylation at Ser616, which amplifies fission activity, whereas suppressed MFN2 expression and aberrant OPA1 processing impair fusion, resulting in widespread mitochondrial fragmentation (Massaad and Klann, 2011

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fumigatus , acidification in phagolysosome is repressed when DHN melanin hampers the endocytic pathway after the uptake by the immune cells (244)

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Besides IGF-1, IGF-2 and its receptor IGF-2R share a similar expression pattern in the developing and mature CNS (229)

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doi: 10.1038/s41598-018-31764-0

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