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Description
Mechanical stress can denature the peptide (= disrupt its three-dimensional structure)
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Illustratively, it is produced in the central nervous system (i.e., brainstems raphe nuclei) (12% of the serotonin in the human body), skin (i.e., Merkel cells), lung (pulmonary neuroendocrine cells), gastrointestinal tract (90% of the serotonin in the human body) (i.e., enterochromaffin cells), and rest of 8% is stored in platelets [166]
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It should not be used in neonates, pregnant women, certain medications, or for intrathecal injection
