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The activity of DHODH influences the vulnerability of cancer cells with low GPX4 levels to ferroptosis, likely due to DHODH-mediated utilization of COQ10 as an electron acceptor in HT1080 and NCI-H226 (human lung cancer cell line) cells [13]

For example, children with MTHFR mutations may benefit from methylated forms of vitamins to bypass metabolic blocks

[DOI] [PMC free article] [PubMed] [Google Scholar] 1366.Perea G, Araque A

Leukemia 1:254, 1987

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