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These findings suggest that the cytotoxic effect of MCNs/Ln/GD/FR NPs on tumors can be enhanced by upregulating cell cycle-related protein expression to inhibit tumor mitosis and downregulating apoptosis-related proteins to promote tumor cell apoptosis

The number of GA (genetic algorithm) runs was set to 30

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Bronstein, "Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease", Proc Natl Acad Sci U S A 110 (2): 636-641 (2013)