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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Xu Q., Zhou L., Yang G., Meng F., Wan Y., Wang L., Zhang L

doi: 10.1038/s41467-022-34096-w

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Moreover, a key challenge is balancing the desired anti-tumor immune effects with potential systemic metabolic side effects, such as dyslipidemia, which has been observed with some FXR agonists (132)
Molecular analysis revealed that Pinealon treatment optimized the Grin2a/Grin2b subunit ratio compared to untreated diabetic controls, indicating improved receptor composition favorable for synaptic plasticity and memory consolidation
