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Description
We discovered a first-in-class inhibitor of the TRF1:TIN2 interaction (compound 40 ) that binds to TRF1 TRFH with a K D of 29 M (95% CI: 2041 M), displaces a TIN2 probe with an IC 50 of 67 M (95% CI: 10120 M), and expels TRF1 from purified shelterin
doi:10.26355/eurrev_201903_17414
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Kaliman P, Alvarez-Lopez MJ, Cosin-Tomas M, Rosenkranz MA, Lutz A, Davidson RJ
Most practitioners recommend a minimum of 90 days of consistent use before evaluating visible outcomes
