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Additionally, embryonic fibroblasts from Mfn1/2 double knockout mice contain numerous fragmented mitochondria

This effect was positively correlated with the upregulation of p53, Caspase-3, and Bcl-2 activities, as well as the downregulation of Bax

According to the study of Shaaban et al., if ASD children aged 59 years are given a supplementation a 3 months supplementation with Lactobacillus acidophilus , Lactobacillus rhamnosus and Bifidobacterium longum, significant improvements emerge in ASD severity, gastrointestinal symptoms, and domains related to social interaction and communication

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