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Pioglitazone, a PPAR agonist, can reduce insulin resistance in peripheral tissues and the liver, improve insulin sensitivity in patients with insulin resistance, enhance insulin responsiveness in cells and improve glucose balance disorders in the body

Lentigo maligna is melanoma Melanoma Melanoma is a malignant tumor arising from melanocytes, the melanin-producing cells of the epidermis

The C/EBP expression in microglia has indeed been observed to increase in spinal cord of ALS animal models and human ALS patients (97).TDP-43 interacts with NF-B, a key factor contributing to the inflammatory response, and activates NF-B in microglia (98)

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Disturbances in the cholesterol synthesis and secretion in astrocytes have been associated with synaptic deficits and neurodegenerative disorders (21, 23, 24, 25, 26, 27, 28, 29)