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Description
Components of the pathway were discovered 30 years ago by different researchers working simultaneously in mouse and Drosophila models (Nusse et al., 1984

2014;211:226.e1226.e7

Yao DL, West NR, Bondy CA, Brenner M, Hudson LD, Zhou J, Collins GH, Webster HD: Cryogenic spinal cord injury induces astrocytic gene expression of insulin-like growth factor I and insulin-like growth factor binding protein 2 during myelin regeneration

A key example of a negative feedback system is the regulation of the thyroid hormone thyroxine, which regulates numerous key metabolic processes

Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH, "GLI2 inhibition abrogates human leukemia stem cell dormancy", J Transl Med 13 (98): 1-14 (2015)
