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The role of creatine in energy metabolism in diseases depends on the CK/PCr system, which provides the metabolic basis on how creatine can affect health and how it can offer therapeutic benefit [88]

On the other hand, AR also utilizes NADPH to convert glucose to sorbitol, which depletes intracellular NADPH, making GSSG irreducible and promoting oxidative stress 18

Biochim Biophys Acta (BBA)Mol Basis Dis 1842:902915 Fields CR, Bengoa-Vergniory N, Wade-Martins R (2019) Targeting Alpha-Synuclein as a Therapy for Parkinsons Disease

[DOI] [PubMed] [Google Scholar] 334.Fisher S.A., Rahimzadeh M., Brierley C., Gration B., Doree C., Kimber C.E., Plaza Cajide A., Lamikanra A.A., Roberts D.J

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