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Immunotherapy targeting Myeloid-Derived suppressor cells (MDSCs) in tumor microenvironment

When a sleep disturbance is determined to be directly and temporally linked to another mental, physical, or sleep problem, comorbid insomnia is diagnosed (Morin & Benca, 2011).The DSM-5 and ICSD-3 criteria require a subjective report of a sleep complaint (difficulty falling asleep, staying asleep, or waking up early) occurring at least three times a week for three months, along with at least one related daytime impairment (fatigue, attention impairment, mood disturbance, or impaired performance), in order to diagnose chronic insomnia (Saddichha, 2010)

Hypothyroidism can result from an autoimmune condition known as Hashimoto's disease , a disease in which the immune system attacks the thyroid gland and prevents it from making enough hormones

The significance of differences between 2 groups was examined using Student t-test or the Wilcoxon signed-rank test