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However, acylcarnitine was shown to reduce the levels of specific claudin proteins and alter the barrier function of tight junctions in Caco-2 cell monolayers and is should be cautiously considered for people who already have intestinal barrier problems [237]

doi: 10.3389/fendo.2020.00160 [DOI] [PMC free article] [PubMed] [Google Scholar]

Building on the essential role of SLC25A45 in TML transport, the authors explored the structural basis for its mechanistic function

Carnitine regulatory abnormalities have been attributed to diabetic complications, trauma, hemodialysis, starvation, obesity, cardiomyopathy, fasting, endocrine imbalances, medication interactions, and other conditions (Guerra et al., 2021)

PMC 3148909