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This induction in BALB/c was entirely dependent on IL-4RA, IgE- and FCER1A-expressing cells and could be partially prevented by pretreating mice with zileuton (ALOX5 inhibitor), montelukast (CysLTR1 inhibitor) or HAMI3379 (CysLTR2 inhibitor) before each challenge (Fig

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4e, 3NP treatment induced a progressive motor impairment in the mice that were pre-injected with the inactive mito GCL (E103A), but not in those pre-injected with the wild-type mito GCL