glutathione n-acetyl-glutamate metabolism Regulation of glutamate homeostasis by N-acetylcysteine (NAC). NAC N-acetylglutamate synthase deficiency: MedlinePlus Genetics

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Dysregulation of this pathway through altered dimerization, post-translational modifications, or impaired regulation contributes to the pathophysiology of Alzheimers disease, Parkinsons disease, Huntingtons disease, and amyotrophic lateral sclerosis, leading to protein aggregation, mitochondrial dysfunction, and neuroinflammation

It is also linked to cystic fibrosis, immune diseases and cardiovascular diseases

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