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A deficiency has been linked to problems with fertility

Why B12 Matters During Breastfeeding Breastfeeding mothers need to pay special attention to their B12 intake because: Your baby relies entirely on your breast milk for their B12 needs B12 deficiency in infants can lead to serious developmental issues Your own stores can become depleted more quickly during lactation Research shows that breast milk B12 levels directly correlate with maternal B12 status

Studies show the consuming an excessive amount of vitamin B12 may: Increase the risk of cardiovascular events in people with diabetic nephropathy : A study published in JAMA sought to determine whether B vitamin therapy was able to slow the progression of diabetic nephropathy (kidney damage due to diabetes) and prevent vascular complications

After the treatment, the rats were fasted for 12 hours and euthanized by an overdose of pentobarbital sodium anesthesia (100 mg/kg i.p.)

I have not been able to do this with heavy exercise or dieting