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Despite these promising findings, current evidence remains largely preclinical

Ong et al., 2020[103]

Antioxidant enzyme activation Studies in aging rats found that epitalon increased the activities of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase

Its synthesis is catalyzed first by glutamate cystine ligase (GCL), which couples to ATP hydrolysis to form an amide bond between the carboxyl group of glutamate and the amino group of cysteine

388,389 Butyrate enhances the integrity of the blood-nerve barrier and reduces inflammatory cytokine production, protecting peripheral nerves from damage