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10.1002/mnfr.201500822 (2016)
Animal models of tinnitus: a review
Due to critical limitations in the treatment of AD, the bloodbrain barrier (BBB) restricts the entry of approximately 98% of the US Food and Drug Administration (FDA)-approved small-molecule drugs as well as most large-molecule therapeutics (Pardridge, 2005)
These occur independently of cell death and involve the expulsion of nuclear chromatin and the release of granule proteins
Any decline in redox enzymes may increase free radical generation with subsequent induction of lipid peroxidation, protein oxidation, and DNA/RNA degradation 557,558,559
